Like son, like father.
نویسنده
چکیده
Pelger-Huet anomaly is a rare autosomal dominant disorder characterized by pince-nez appearance of the nuclei of the neutrophils. This is caused by failure of nuclear segmentation due to genetic defect in the LBR (laminin B-receptor) on the chromosome 1q41-43. Heterozygotes have dumbbell-shaped or hyposegmented neutrophils with coarse chromatin and normal granules. Homozygotes have neutrophils with a single, round, eccentric nucleus with clumped chromatin and no nuclear segmentation. It is important to recognize Pelger-Huet anomaly as a benign condition. An acquired abnormality is referred to as pseudo Pelger-Huet anomaly. This may occur in myelodysplastic disorders, myeloproliferative diseases, and acute and chronic leukemias, reactions to drugs, and so on. The history and peripheral smear make the differential between congenital Pelger-Huet and acquired.
منابع مشابه
LIKE FATHER, LIKE SON The Relationships between Conviction Trajectories of Fathers and their Sons and Daughters
متن کامل
Like father, like son
Exposing male mice to nicotine or cocaine enables their male offspring to cope with high doses of either, which suggests that such paternal effects are generic, rather than being a response to a specific type of stress.
متن کاملIntergenerational Education Mobility in India
Like Father, Like Son? Intergenerational Education Mobility in India An important constraint in studying intergenerational education mobility for India is the lack of data that contain information about parents’ education for the entire adult population. This paper employs a novel strategy to create a unique father-son matched data that is representative of the entire adult male population in I...
متن کاملEffectiveness of concepts of reality therapy on parent-child conflicts father-son and self-esteem in male adolescents in Ilam province
Reality therapy is a particular approach in adolescent development and independence that repeatedly emphasized on the disagreeable relationships and self-control to encourage personal growth. Unfortunately, we could not find any study in the context of effectiveness of training reality therapy concepts on parent-child conflicts and self-efficacy. Therefore, this study were done with the purpose...
متن کاملA FACS Based Case Study on Two HbE-β Thalassaemia Members of a Family, Having Similar Mutational Background
In this report we have tried to explain the reasons behind the difference in the pattern of transfusion requirement between two members of a family with similar β-globin mutation. The father and younger son both are HbE-β, but the father never had transfusion, whereas the younger son takes transfusion monthly. Mother and the elder son are HbEE without any history of transfusion. β-globin mutati...
متن کاملWilliam James Morton [1845-1920]: like father, like son (?).
William Thomas Green Morton, the man most commonly associated with the introduction of anesthesia in 1846, fathered William James Morton. William James Morton's contributions to society were substantial. He conducted pioneering work in radiology, radiation oncology, and therapeutic electricity. He authored numerous textbooks and articles, and he was an editor of a journal on human behavior. His...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Blood
دوره 120 24 شماره
صفحات -
تاریخ انتشار 2012