Like son, like father.

نویسنده

  • Jayashree D Kulkarni
چکیده

Pelger-Huet anomaly is a rare autosomal dominant disorder characterized by pince-nez appearance of the nuclei of the neutrophils. This is caused by failure of nuclear segmentation due to genetic defect in the LBR (laminin B-receptor) on the chromosome 1q41-43. Heterozygotes have dumbbell-shaped or hyposegmented neutrophils with coarse chromatin and normal granules. Homozygotes have neutrophils with a single, round, eccentric nucleus with clumped chromatin and no nuclear segmentation. It is important to recognize Pelger-Huet anomaly as a benign condition. An acquired abnormality is referred to as pseudo Pelger-Huet anomaly. This may occur in myelodysplastic disorders, myeloproliferative diseases, and acute and chronic leukemias, reactions to drugs, and so on. The history and peripheral smear make the differential between congenital Pelger-Huet and acquired.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Like father, like son

Exposing male mice to nicotine or cocaine enables their male offspring to cope with high doses of either, which suggests that such paternal effects are generic, rather than being a response to a specific type of stress.

متن کامل

Intergenerational Education Mobility in India

Like Father, Like Son? Intergenerational Education Mobility in India An important constraint in studying intergenerational education mobility for India is the lack of data that contain information about parents’ education for the entire adult population. This paper employs a novel strategy to create a unique father-son matched data that is representative of the entire adult male population in I...

متن کامل

Effectiveness of concepts of reality therapy on parent-child conflicts father-son and self-esteem in male adolescents in Ilam province

Reality therapy is a particular approach in adolescent development and independence that repeatedly emphasized on the disagreeable relationships and self-control to encourage personal growth. Unfortunately, we could not find any study in the context of effectiveness of training reality therapy concepts on parent-child conflicts and self-efficacy. Therefore, this study were done with the purpose...

متن کامل

A FACS Based Case Study on Two HbE-β Thalassaemia Members of a Family, Having Similar Mutational Background

In this report we have tried to explain the reasons behind the difference in the pattern of transfusion requirement between two members of a family with similar β-globin mutation. The father and younger son both are HbE-β, but the father never had transfusion, whereas the younger son takes transfusion monthly. Mother and the elder son are HbEE without any history of transfusion. β-globin mutati...

متن کامل

William James Morton [1845-1920]: like father, like son (?).

William Thomas Green Morton, the man most commonly associated with the introduction of anesthesia in 1846, fathered William James Morton. William James Morton's contributions to society were substantial. He conducted pioneering work in radiology, radiation oncology, and therapeutic electricity. He authored numerous textbooks and articles, and he was an editor of a journal on human behavior. His...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:
  • Blood

دوره 120 24  شماره 

صفحات  -

تاریخ انتشار 2012